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Therapeutic effects of anidulafungin, caspofungin and micafungin on P. murina cysts and trophic forms.

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posted on 2010-01-29, 01:23 authored by Melanie T. Cushion, Michael J. Linke, Alan Ashbaugh, Tom Sesterhenn, Margaret S. Collins, Keeley Lynch, Ronald Brubaker, Peter D. Walzer

Data in all panels represents mice treated 3 times per week for 3 weeks with anidulafungin (green bars), caspofungin (yellow bars), micafungin (blue bars) at the doses noted and trimethoprim-sulfamethoxazole at 50/200 mg/kg (pink bars, T/S) or untreated (red bars, C/S). Bars indicate log10 mean cysts±standard deviation (SD) per lung. Panel A: High dose echinocandin treatment, cyst burdens. All groups were significantly different than the untreated control mice (C/S), P<0.001. Panel B: Low dose echinocandin treatment, cyst burdens. Cyst burdens were compared to untreated controls (C/S) and P values for each group are listed on the graph; (*) indicates P<0.001. Panel C: High dose echinocandin treatment, trophic burdens *P<0.001 treated vs untreated control mice (C/S). Panel D: Low dose echinocandin treatment, trophic burdens. *P<0.001 treated vs untreated control mice.