The virtual lobule morphology is constructed iteratively.

<p>First, sinusoids outward from the central vein (i). In addition to small random variations in the direction of propagation, the sinusoids branch into two sinusoids pointed away from the central vein with probability P_br (ii). Multiple sinusoids are started from the central vein in an attempt to fill space (iii). Portal “triads” consisting of arterioles and venules through which blood enters the lobule are added to the perimeter of the lobule and connected to the vasculature (iv). Finally, the sinusoids are lined with hepatocytes as space allows (v).</p>