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The up-regulation of RUNX3 repressed prostate cancer metastasis in vivo.

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posted on 24.01.2014, 03:34 authored by Feifei Chen, Meng Wang, Jin Bai, Qinghua Liu, Yaguang Xi, Wang Li, Junnian Zheng

A Mice were injected with were injected via tail vein with DU145 cells transfected with the indicated expression plasmids. Groups contained 8 mice. Eight weeks later, mice were sacrificed and the lung metastasis of DU145 cells was measured by macroscopic after autopsy. Histologic analysis of metastatic lesions in the ribs of nude mice was carried by HE staining. B Quantification of nodules in lung with altered RUNX3 levels. The numbers of nodules were blindly evaluated in 5 random fields per implant at 200 magnifications. Data are shown as mean ± S.D. *P<0.05. C Representative immunohistochemical photographs of PAP expression in lung tissue (magnifications, ×200 and ×400). *Tumor tissue.