The suppressive effect of IPA-3 in nude mouse xenograft model.

<p>(<b>A</b>) MHCC97L cells were used for the xenograft model. Mice were treated three times weekly either with DMSO or IPA-3 (2 mg/kg or 4 mg/kg, i.p.). *<i>P</i><0.001 (ANOVA) compared with the DMSO control group. (<b>B</b>) Tumor weights were measured at the end of study. *<i>P</i><0.001, **<i>P</i><0.01, (ANOVA) compared with the DMSO control group. (<b>C</b>) Representative results of Western blotting analysis. P-PAK1 (T423), total PAK1, P-JNK and total JNK were detected. ***<i>P</i><0.05 (ANOVA) compared with the DMSO control. Error bars, mean ± SD of 5 animals per group.</p>