The sequence logos of three conserved motifs in subgroups of HES/HEY genes.
figureposted on 2012-07-13, 00:00 authored by Mi Zhou, Jun Yan, Zhaowu Ma, Yang Zhou, Nibras Najm Abbood, Jianfeng Liu, Li Su, Haibo Jia, An-Yuan Guo
The Motif 1 was created using an alignment of HEY1/2/L sequences near bHLH domain. The similar process was used to get Motif 2 (DEC1/2 sequence near Orange domain) and Motif 3 (DEC1 sequence in C-terminal). The overall height of each stack indicates the sequence conservation at that position, whereas the height of symbols within each stack reflects the relative frequency of the corresponding amino acid.