The schematic structure and the mutations of the human myosin XVa.

The myosin XVa consists of 3530 amino acids, including an N-terminal extension domain and Motor domain, two light chain binding IQ motifs, two myosin-tail homology 4 (MyTH4) domains and band 4.1/ezrin/radixin/moesin (FERM) domains, a Src-homology-3 (SH3) domain and a C-terminal class I PDZ-ligand domain. The novel MYO15A mutation in this study is showed with red box at the bottom of the figure, and previously reported mutations are displayed at the top of the figure. MYO15A, the myosin XVa gene.