The proposed schematic action of miRNAs in Shiga toxin associated typical HUS is shown.
Figures are generally photos, graphs and static images that would be represented in traditional pdf publications.
Shiga toxin targets and destroys endothelial cells, thereby inducing the detrimental cascade of platelet consumption, fragmentation of red blood cells and thrombotic microangiopathy. Endothelial apoptosis results in an induction of miR-24 and miR-126. MiR-24 is subsequently released to the circulation and perpetuates the disease process by activating adjacent endothelial cells. MiR-126 in apoptotic bodies sends survival signals to adjacent endothelium.