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The proposed schematic action of miRNAs in Shiga toxin associated typical HUS is shown.

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posted on 19.02.2013 by Johan M. Lorenzen, Jan Menne, Bernhard MW. Schmidt, Mascha Schmidt, Filippo Martino, Robert Dietrich, Senguel Samiri, Hans Worthmann, Meike Heeren, Karin Weissenborn, Hermann Haller, Mario Schiffer, Jan T. Kielstein, Thomas Thum

Shiga toxin targets and destroys endothelial cells, thereby inducing the detrimental cascade of platelet consumption, fragmentation of red blood cells and thrombotic microangiopathy. Endothelial apoptosis results in an induction of miR-24 and miR-126. MiR-24 is subsequently released to the circulation and perpetuates the disease process by activating adjacent endothelial cells. MiR-126 in apoptotic bodies sends survival signals to adjacent endothelium.

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