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The number of Th17 cells in the spleen and cardiac tissue is decreased by Ad-IL-17AR:Fc.

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posted on 20.08.2013, 01:41 by Yuquan Xie, Minghui Li, Xinggang Wang, Xian Zhang, Tianqing Peng, Yingzhen Yang, Yunzeng Zou, Junbo Ge, Haozhu Chen, Ruizhen Chen

(A) Representative flow cytometry images of Th17 (CD4+ IL-17+) cells from each group gated on CD4+ T cells. Numbers in the upper right quadrants and lower right quadrants indicate the separate percentages of Th17 cells and CD4+ T cells, respectively. PE = phycoerythrin; FITC = fluorescein isothiocyanate. (B) The percentage of Th17 (CD4+ IL-17+) cells in each group was analyzed using CellQuest software. (C) The levels of IL-6 and TNF-α in the supernatants of heart homogenates detected using ELISA. The data represent the mean ± SEM for 6 mice per group. **P<0.01 vs control group, *p<0.05 vs control group.