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The four miRNAs co-regulate cyclin D1 expression.

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posted on 30.09.2013, 07:36 by Ling Tian, Yu-xiang Fang, Jing-lun Xue, Jin-zhong Chen

Overexpression of miR-19b, miR-23b, miR-26a or miR-92a up-regulated cyclin D1 expression in DU145 (A) and PNT1B (C), while neutralization of each miRNA alone repressed the cyclin D1 expression in DU145 (B) and PNT1B (D). The expression of cyclin D1 was measured by qRT-PCR and western blot. The relative quantification of PTEN protein was measured by densitometry.

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