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The expression of MMP-7 within atherosclerotic carotid plaques in relation to plaque symptomatology.
figure
posted on 2014-01-06, 02:50 authored by Azhar Abbas, Pål Aukrust, David Russell, Kirsten Krohg-Sørensen, Trine Almås, Dorte Bundgaard, Vigdis Bjerkeli, Ellen Lund Sagen, Annika E. Michelsen, Tuva B. Dahl, Sverre Holm, Thor Ueland, Mona Skjelland, Bente HalvorsenmRNA (A) and protein (B) levels of MMP-7 in atherosclerotic carotid plaques were measured in (i) patients with the most recent symptoms (within the last 2 months, n = 35) and (ii) patients with symptoms >2 months ago and asymptomatic patients (>2 months, n = 29). For comparison, mRNA levels of MMP-7 were also analyzed in non-atherosclerotic vessels (common iliac artery) from 10 organ donors (CTR). mRNA levels were quantified by real-time RT-PCR. The expression of β-actin was used as endogenous control. Protein levels of MMP-7 were measured in plaque lysates by EIA. Data are shown as a box and whisker plot with median (Q1, Q3) in the box and the whiskers representing the 5 and 95 percentile in relation to β -actin expression.
