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The expression of HOTAIR in human gastric carcinoma tissues.

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posted on 10.10.2013, 07:45 by Hiroyuki Endo, Takeharu Shiroki, Takayuki Nakagawa, Misa Yokoyama, Keiichi Tamai, Hideaki Yamanami, Tsuneaki Fujiya, Ikuro Sato, Kazunori Yamaguchi, Nobuyuki Tanaka, Katsunori Iijima, Tooru Shimosegawa, Kazuo Sugamura, Kennichi Satoh

A, HOTAIR expression levels of cancerous and adjacent noncancerous tissues from the gastric cancer patients were examined by qRT-PCR and normalized by the GAPDH expression level. The expression levels of HOTAIR were significantly higher in carcinoma lesions compared to those of non-cancerous lesions (P= 0.019). B and C, The human gastric cancer tissues were further classified according to the HOTAIR expression level into a High-HOTAIR group (HOTAIR / GAPDH >1.0) and Low-HOTAIR group (HOTAIR /GAPDH < 1.0) in the intestinal (B) and diffuse type (C) of gastric cancer, respectively.

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