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The effectiveness of HPV vaccination depends on which sex is being vaccinated and on the heterogeneity in sexual behavior.

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posted on 20.12.2011, 00:10 by Johannes A. Bogaards, Mirjam Kretzschmar, Maria Xiridou, Chris J. L. M. Meijer, Johannes Berkhof, Jacco Wallinga

(A) The equilibrium prevalence of HPV16 infection in relation to immunization coverage by vaccinating girls only, boys only, or both girls and boys at an equal rate. (B) The equilibrium prevalence of HPV16 infection in relation to female immunization coverage for various assumptions of heterogeneity in sexual behavior. Results in (A) assume three dynamic activity classes plus an age-specific partner preference function. The default parameters were obtained by fitting this model to prevaccine data on HPV16 infection in the Netherlands [26].

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