The effect of imatinib (A) or nilotinib (B) on the accumulation of [³H]-paclitaxel in HEK293-pcDNA3.1 and HEK-MRP7-2 cells.

The intracellular paclitaxel accumulations in HEK293-pcDNA3.1 and HEK-MRP7-2 cells were measured after the incubation with 0.1 µM paclitaxel. Intracellular accumulation of paclitaxel in HEK293-pcDNA3.1 cells in the absence of imatinib and nilotinib were shown in the left bars (▪). Intracellular accumulation of paclitaxel in the presence of 5 µM of imatinib in HEK293-pcDNA3.1 cells was shown on the right (□). Intracellular accumulation of paclitaxel in HEK-MRP7-2 cells in the presence of 5 µM of nilotinib was shown on the right (). Each column represents the means (±SD). All experiments were done in triplicate. * p<0.05, Student's t test.