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The effect of imatinib (A) or nilotinib (B) on the accumulation of [3H]-paclitaxel in HEK293-pcDNA3.1 and HEK-MRP7-2 cells.

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posted on 21.02.2013, 04:10 authored by Tong Shen, Ye-Hong Kuang, Charles R. Ashby Jr, Yu Lei, Angel Chen, Ying Zhou, Xiang Chen, Amit K. Tiwari, Elizabeth Hopper-Borge, Jiangyong Ouyang, Zhe-Sheng Chen

The intracellular paclitaxel accumulations in HEK293-pcDNA3.1 and HEK-MRP7-2 cells were measured after the incubation with 0.1 µM paclitaxel. Intracellular accumulation of paclitaxel in HEK293-pcDNA3.1 cells in the absence of imatinib and nilotinib were shown in the left bars (▪). Intracellular accumulation of paclitaxel in the presence of 5 µM of imatinib in HEK293-pcDNA3.1 cells was shown on the right (□). Intracellular accumulation of paclitaxel in HEK-MRP7-2 cells in the presence of 5 µM of nilotinib was shown on the right (). Each column represents the means (±SD). All experiments were done in triplicate. * p<0.05, Student's t test.

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