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The effect of age on the number of heteroplasmies in the unrelated SardiNIA sequencing project participants.

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posted on 14.07.2015, 03:37 by Jun Ding, Carlo Sidore, Thomas J. Butler, Mary Kate Wing, Yong Qian, Osorio Meirelles, Fabio Busonero, Lam C. Tsoi, Andrea Maschio, Andrea Angius, Hyun Min Kang, Ramaiah Nagaraja, Francesco Cucca, Gonçalo R. Abecasis, David Schlessinger

The number of heteroplasmies increases with age with different (colored) minor allele fraction (MAF) thresholds. Each line plots the expected number of heteroplasmies based on the Poisson loglinear model against age at an MAF threshold; while the points represent the observed mean number of heteroplasmies in each age group (<40, 40–50, 50–60, 60–70, 70–80, >80).