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The cooperation of PPARα and ATF4 in increased FGF21 expression after acute exercise or FFA treatment.

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posted on 2013-05-07, 02:33 authored by Kook Hwan Kim, Seong Hun Kim, Young-Ki Min, Hun-Mo Yang, Jeong-Beom Lee, Myung-Shik Lee

(A) Relative PPARα, ATF4 and ATF3 mRNA levels in the liver of mice before (pre-Ex) and immediately after (post-Ex) a single bout of acute exercise (n = 4). (B–C) Relative mRNA levels of FGF21 (B) and ATF4 (C) in FaO cells after treatment with 2% FFA-free BSA (Con), BSA-conjugated palmitic acid (400 µM, PA) or BSA-conjugated oleic acid (400 µM,OA) for 6 h (n = 4). (D) Luciferase activity of FGF21 promoter in FaO cells transfected with PPARα or ATF4 for 24 h. Data are mean ± SEM (*P<0.05 and **P<0.01 by Mann-Whitney test).