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The canonical E-box sequence CATGTG is not preferred by Myc.

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posted on 2008-03-12, 01:41 authored by Jonghwan Kim, Ji-hoon Lee, Vishwanath R. Iyer

The relationship between the presence of six E-box sequences in the promoter (between −800 bp and +200 bp of TSS) and Myc binding was analyzed. (A) Top and bottom 2% Myc occupancy data and (B) top and bottom 10% of Myc occupancy data were used. Black bars in both panels represent target promoters that were occupied by Myc and gray bars represent promoters that were not occupied by Myc. Promoters that contained the E-box sequence CATGTG did not show a positive correlation with Myc binding.