TVV+MM protects mice against avian H5N1.
Mice (n = 9-10/group) were immunized 1x or 2x with TVV with or without MM. Four weeks later, mice were challenged with 25xLD50 wild-type A/Hong Kong /156/97 (H5N1) and monitored for 21 days for survival, body weight loss and clinical symptoms. Graphs represent the Kaplan-Meier survival curve (A and D) or mean bodyweight change with 95% confidence interval (B and E) or mean clinical scores with interquartile range (C and F). Asterisks indicate statistically significant differences compared to the vehicle control group (*p<0.05, **p<0.01, ***p<0.001, according to the materials and methods section).