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TRPV1 in brain mediates the antinociceptive effects of 4-aminophenol and 4-hydroxy-3-methoxybenzylamine (HMBA).

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posted on 2013-08-05, 03:32 authored by David A. Barrière, Christophe Mallet, Anders Blomgren, Charlotte Simonsen, Laurence Daulhac, Frédéric Libert, Eric Chapuy, Monique Etienne, Edward D. Högestätt, Peter M. Zygmunt, Alain Eschalier

Intracerebroventricular injection of the TRPV1 blocker capsazepine (Cz) prevented the antinociceptive effect of 4-aminophenol (A; n = 5–7) and HMBA (B; n = 6–8) in the mouse formalin test. 4-aminophenol (30 mg/kg) and HMBA (100 mg/kg) were injected by the intraperitoneal route 10 min before the test. Capsazepine (100 nmol) was injected 5 min before the 4-aminophenol and HMBA administration. **p<0.01 when compared to vehicle injection, using Mann-Whitney U test.