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TLR9 deficiency prevents hepatic injury.

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posted on 11.09.2015 by Pieter J. Bakker, Angelique M. Scantlebery, Loes M. Butter, Nike Claessen, Gwendoline J. D. Teske, Tom van der Poll, Sandrine Florquin, Jaklien C. Leemans

Liver damage was assessed using plasma alanine aminotransferase (ALAT) (A) and aspartate aminotransferase (ASAT) (B) in wild-type (Wt) and TLR9 deficient (TLR9KO) mice subjected to moderate (20 minutes ischemia) or severe (30 minutes ischemia) renal injury after one day. Plasma LDH levels were correlated to plasma ALAT (C) or plasma ASAT (D) levels (n = 7-13/group). Haematoxylin-eosin staining of liver sections (200x) of wild-type (E) and TLR9KO (F) mice subjected to severe renal ischemia after one day. Correlations were performed using the non-parametric Spearman test. Two group comparisons were performed using Mann-Whitney where p < 0.05 = *.