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TCDD and FICZ administration inhibit EAE establishment and dampen T cell expansion and infiltration of the central nervous system.

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posted on 14.11.2013, 03:46 by João H. Duarte, Paola Di Meglio, Keiji Hirota, Helena Ahlfors, Brigitta Stockinger

A) Clinical scores of mice immunized with MOG/CFA which received either vehicle (filled circles), TCDD (inverted triangles) or FICZ (filled squares) i.p. at the time of immunization; table showing incidence, mean day of onset and mean maximum score of disease. Data shown as mean ± SEM are representative of 2 independent experiments, ***p<0.001, **p<0.01 in two-way ANOVA followed by Dunnet post-test. B) Number of IL-17A+, and number and frequency of Foxp3+ T cells recovered from draining lymph nodes on day 6 post immunization in mice that received TCDD. Data shown as mean ± SEM are representative of 2 independent experiments. *p<0.05 in Student’s T test. C) Number of IL-17A+, IFN-γ+ and Foxp3+ T cells, and frequency of Foxp3+ T cells recovered from the spinal cord on day 15 post immunization in mice that received TCDD. Data shown as mean ± SEM are representative of 2 independent experiments. *p<0.05 in Student’s T test. D) Number of IL-17A+, and number and frequency of Foxp3+ T cells recovered from draining lymph nodes on day 6 post immunization in the presence of FICZ. E) Number of IL-17A+, IFN-γ+ and Foxp3+ T cells, and frequency of Foxp3+ T cells recovered from the spinal cord on day 15 post immunization in mice that received FICZ. Data shown as mean ± SEM are representative of 2 independent experiments.

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