Systemic recurrence: PCA of predicted PIs from converged gene sets and performance of the resulting groups from PC1.

Results for systemic recurrence are in (A-B); for BC specific death in (C-D). (A) Scatter plot of predicted PIs from 9 converged gene-set models on the space of the top two leading PCs. Black circles indicate censored observations; red dots indicate patients with relapse. (B) The Kaplan-Meier curves for high and low risk groups are significantly different (χ² = 8.76, df = 1, p = 0.003). (C) Scatter plot of predicted PIs from 10 converged gene-set models on the space of the top two leading PCs. Black circles indicate censored observations; red dots indicate patients with BC specific death; brown stars indicate death from other reasons. (D) The Kaplan-Meier curves for high and low risk groups are significantly different (χ² = 10.26, df = 1, p = 0.001).