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Synthetic E-peptide sequences.

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posted on 19.02.2013, 22:51 by Becky K. Brisson, Elisabeth R. Barton

A. Rodent Igf1 3′ splicing leads to two mRNA isoforms. While mature IGF-I is encoded by exons 3 and 4, the E-peptides are encoded by exons 4, 5, and/or 6. EA isoforms exclude exon 5, while EB isoforms retain exon 5, leading to an altered reading frame and earlier stop codon in exon 6. Exons not drawn to scale B. Synthetic E-peptide amino acid sequences. EA and EB are less than 50% identical. Scr = Scrambled peptide. * = potential glycosylation sites in EA. The portion of EB that corresponds to MGF is underlined.

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