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Sodium channel properties in wt and dystrophic neonatal cardiomyocytes.

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posted on 20.02.2013, 18:09 by Xaver Koenig, Sandra Dysek, Stefanie Kimbacher, Agnes K. Mike, Rene Cervenka, Peter Lukacs, Katrin Nagl, Xuan B. Dang, Hannes Todt, Reginald E. Bittner, Karlheinz Hilber

A. Original current traces of a typical wt, mdx, and mdx-utr cardiomyocyte, elicited by depolarising voltage-steps. B. Current-voltage relationships derived from a series of experiments as shown in A. The Inset (bar graph) shows a comparison of the maximum current densities between wt and dystrophic cardiomyocytes. C. Comparison of the current decay kinetics between wt and dystrophic cardiomyocytes at different membrane voltages. Decay half-times represent the time periods between the current peak and the time point at which the current had decayed to 50%. * indicates that ANOVA revealed a significant difference (p<0.05) between the respective parameters of the three tested groups. Tukey's Post Hoc test for comparison between two groups revealed significant differences (p<0.05) between mdx-utr and wt, and between mdx-utr and mdx. D. Voltage-dependencies of activation and steady-state inactivation in wt and dystrophic cardiomyocytes. E. Recovery from inactivation in wt and dystrophic cardiomyocytes. Data were fit with a single exponential function. The pulse protocols are shown as insets in the respective graphs. Data points represent means ± SEM. Detailed statistics and n-values are given in Table 1.

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