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Slow dissipation of RPA-1 and RAD-51 foci induced by ICLs in mitotic germ cells of jmjd-1.1 mutant worms.

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posted on 2015-04-08, 04:07 authored by Changrim Lee, Seokbong Hong, Min Hye Lee, Hyeon-Sook Koo

Prolonged accumulations of (A) RPA-1 (C. elegans RPA70 homolog) and (B) RAD-51 (C. elegans RAD51 homolog) foci upon ICL formation in the nuclei of mitotic germ cells of jmjd-1.1 worms. L4 stage worms were exposed to trimethyl psoralen as in Fig 3, and gonads were immuno-stained with the indicated antibodies at 6, 12, 18 and 24 h post treatment (with an additional time point at 9 h in (B)). Scale bar, 10 μm.