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Skeletally mature Colα1(I) 2.3-Cre;Kif3afl/fl mice exhibit less responsiveness to mechanical loading compared to control mice.

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posted on 2013-02-20, 07:56 authored by Sara Temiyasathit, W. Joyce Tang, Philipp Leucht, Charles T. Anderson, Stefanie D. Monica, Alesha B. Castillo, Jill A. Helms, Tim Stearns, Christopher R. Jacobs

(A) Representative images of non-loaded (left) and loaded (right) ulnae of Colα1(I) 2.3-Cre;Kif3afl/fl (top) and control (bottom) mice. Fluorochrome labels (Calcein-green and Alizarin Red-red) given on Days 5 and 12 after the onset of mechanical loading. (B to D) Relative mineralizing surface (rMS/BS, %, B), mineral apposition rate (rMAR, µm per day, C), and bone formation rate (rBFR/BS, µm3/µm2 per year, D) of mechanically loaded mice. Colα1(I) 2.3-Cre;Kif3afl/fl mice exhibited a decrease of 32% in rMAR and 33% in rBFR/BS when compared to control mice. Data presented as mean ± SEM. * p<0.05.

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