Sitagliptin attenuated AAA formation in Ang II-infused apoE-/- mice.
(A) Histogram representing the percent incidence of AAAs for each treatment group. (n = 10–25 per group) (B) Representative photographs showing the features of aneurysms induced by Ang II. The arrow indicates typical AAAs. (C) Quantification of the maximal outer diameters of the suprarenal aortas in apoE-/- mice infused with NS or Ang II given as percentages. (*P < 0.05, n = 10 per group) (D) Representative staining with H&E of the suprarenal aortas of mice. The magnification of images shown is 40x. (n = 5 per group) (E and F) Quantification of the luminal diameters and wall thickness of suprarenal aortas in apoE-/- mice infused with NS or Ang II given as percentages. (*P < 0.05, n = 5 per group).