Single therapies using anti-IL2 (Iδ) or anti-IFNg (Iγ).
The system is first allowed to reach low steady states of all variables, and then exposed to a square pulse of antigen (with amplitude A = 100) from t = 20 to t = 70 to obtain a sarcoid state. As shown in (A) and (B), the model predicts that there is a threshold of anti-IL2 (between amplitudes Iδ = 29 and Iδ = 30) that will push the steady state of R to a low level, but not T and M. The anti-IL2 therapy is represented by asquare pulse of Id given between t = 100 and t = 120. And as shown in (C) and (D), the model also predicts that there is a threshold of anti-IFNγ (between amplitudes Iγ = 15 and Iγ = 16) that will push the steady state of M to a low level, but not T and R. The anti-IFNγ therapy is represented by a square pulse of Iγ given between t = 100 and t = 150. All parameters as in Table 2, except k2a = 2.1.