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Single therapies using anti-IL2 (Iδ) or anti-IFNg (Iγ).

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posted on 27.05.2011 by Baltazar D. Aguda, Clay B. Marsh, Michael Thacker, Elliott D. Crouser

The system is first allowed to reach low steady states of all variables, and then exposed to a square pulse of antigen (with amplitude A = 100) from t = 20 to t = 70 to obtain a sarcoid state. As shown in (A) and (B), the model predicts that there is a threshold of anti-IL2 (between amplitudes Iδ = 29 and Iδ =  30) that will push the steady state of R to a low level, but not T and M. The anti-IL2 therapy is represented by asquare pulse of Id given between t = 100 and t = 120. And as shown in (C) and (D), the model also predicts that there is a threshold of anti-IFNγ (between amplitudes Iγ = 15 and Iγ = 16) that will push the steady state of M to a low level, but not T and R. The anti-IFNγ therapy is represented by a square pulse of Iγ given between t = 100 and t = 150. All parameters as in Table 2, except k2a = 2.1.

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