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Single JD root-mean-square fluctuations (RMSF).

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posted on 2014-09-30, 03:47 authored by Marco A. Deriu, Gianvito Grasso, Ginevra Licandro, Andrea Danani, Diego Gallo, Jack A. Tuszynski, Umberto Morbiducci

Fluctuations of α4 are zoomed in the top-right panel where it is worth noticing that residues Leu84-Trp87 increase the RMSF as a consequence of JD dimerization (black curve). After Ala-mutation (gray curve) on Arg101-/Arg103 the RMSF value decrease to the value achieved by JDWat (light gray curve).