Figure 5.TIF (765.05 kB)
Single JD root-mean-square fluctuations (RMSF).
figure
posted on 2014-09-30, 03:47 authored by Marco A. Deriu, Gianvito Grasso, Ginevra Licandro, Andrea Danani, Diego Gallo, Jack A. Tuszynski, Umberto MorbiducciFluctuations of α4 are zoomed in the top-right panel where it is worth noticing that residues Leu84-Trp87 increase the RMSF as a consequence of JD dimerization (black curve). After Ala-mutation (gray curve) on Arg101-/Arg103 the RMSF value decrease to the value achieved by JDWat (light gray curve).
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polyglutamine tract expansionubiquitin binding sitesJD-JDSCAJosephin Domain Protein-Protein InteractionJD aggregationJD protein-protein interaction3 N-terminal Josephin DomainMolecular Dynamics Spinocerebellar ataxiaJD interaction surfacesJD clumping mechanismJD binding eventhairpin open-like conformation
