figshare
Browse
- No file added yet -

Single JD root-mean-square fluctuations (RMSF).

Download (0 kB)
figure
posted on 2014-09-30, 03:47 authored by Marco A. Deriu, Gianvito Grasso, Ginevra Licandro, Andrea Danani, Diego Gallo, Jack A. Tuszynski, Umberto Morbiducci

Fluctuations of α4 are zoomed in the top-right panel where it is worth noticing that residues Leu84-Trp87 increase the RMSF as a consequence of JD dimerization (black curve). After Ala-mutation (gray curve) on Arg101-/Arg103 the RMSF value decrease to the value achieved by JDWat (light gray curve).

History

Usage metrics

    PLOS ONE

    Categories

    Keywords

    polyglutamine tract expansionubiquitin binding sitesJD-JDSCAJosephin Domain Protein-Protein InteractionJD aggregationJD protein-protein interaction3 N-terminal Josephin DomainMolecular Dynamics Spinocerebellar ataxiaJD interaction surfacesJD clumping mechanismJD binding eventhairpin open-like conformation

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC