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Similarities and differences between the structures of LASV L endonuclease domain and those of other negative-strand RNA viruses.

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posted on 07.02.2014, 11:36 by Gregor D. Wallat, Qinfeng Huang, Wenjian Wang, Haohao Dong, Hinh Ly, Yuying Liang, Changjiang Dong

Like in figure 1, the LASV L endonuclease domain is rainbow-colored. A, Structure of the LASV L endonuclease overlapping LCMV L endonuclease domain (orange). The residues are numbered based on the LASV L sequence. B, Superimposition of the structure of the LASV L endonuclease domain with the LACV L endonuclease domain (magenta). The magnesium ion of LACV is shown in gray, which is close to the position of the first magnesium ion in the LASV structure. C, Superimposition of LASV L endonuclease domain with influenza PA endonuclease domain (gray). The magnesium ion (gray sphere) from the structure of the influenza PA endonuclease is located close to the second magnesium ion of the LASV L endonuclease.

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