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Significant improvement of graft function, graft histology and significant reduction in graft cell infiltration with Fenofibrate treatment.

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posted on 2013-02-20, 02:05 authored by Silke Roedder, Naoyuki Kimura, Homare Okamura, Szu-Chuan Hsieh, Yongquan Gong, Minnie M. Sarwal

Palpated graft beating in transplanted mice was assessed daily and assigned a beating score (BS). Transplanted mice BS were significantly improved when treated with Fenofibrate (FF) compared to non- treated ones (NT) (n = 6, p<0.001; shown are mean BS plus SEM), (a). H&E stainings of mice grafts at POD7 revealed decreased cellular infiltrates and histological damage upon Fenofibrate treatment (b). FACS of infiltrating cells from the same grafts showed significantly reduced numbers of infiltrating innate and adaptive immune cells in the Fenofibrate treated mice (*p<0.05, **p<0.01, 2-sided Student T-test, n = 6). Box Plots show median and first and third quartiles of infiltrating cells corrected for total number of infiltrating cells and total graft weight.