Sequential changes of the predicted leptospiral OMP genes.
The balance between up-regulation (red) and down-regulation (green) indicated that L. interrogans altered its membrane in the infection models. The highly down-regulated transmembrane OMP and lipoprotein genes were clustered into two distinct subclades. The most highly down-regulated subclade included the genes of LipL41 (LA0616), LipL48 (LA3240), a putative OMPs (LA1538), OmpL1 (LA3138) and LipL32 (LA2637). Another highly down-regulated subclade included the genes of LipL21 (LA0011), LipL46 (LA2024), two putative outer membrane proteins (LA0100 and LA2066), LipL45 (LA2295), putative lipoprotein qlp42 (LA0136), Loa22 (LA0222), LruB (LA3469) and LruA/LipL71 (LA3097).