Figure_1.tif (4.72 MB)

Scheme of the experimental protocol for cell line establishment either fresh from surgery specimens ( = patient-derived cell line) of following xenografting in nu/nu mice ( = xenopatient-derived cell line).

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posted on 19.02.2013 by Claudia Maletzki, Saskia Stier, Ulrike Gruenert, Michael Gock, Christiane Ostwald, Friedrich Prall, Michael Linnebacher

Established cell lines were comprehensively characterized and routinely cyropreserved together with xenograft-tissue, immune cells, serum, and normal as well as primary tumor tissue in a biobank. This procedure leads to generation of individualized, patient-derived tumor models available for functional analyses.