Schematic summarizing the lineage tracing experiments to define the fate of ghrelin-labeled cells in the pancreas of Ghrl-Cre;R26-TOM mice.
Figures are generally photos, graphs and static images that would be represented in traditional pdf publications.
Ghrelin-expressing cells are rare in the adult pancreas; however cells that formerly expressed ghrelin or their progeny contribute to the final set of endocrine cells in the islet, specifically within the alpha and PP cells. Interestingly, not all α and PP cells are descendants of ghrelin-expressing cells, suggesting that two distinct populations of glucagon- and PP-expressing cells inhabit the adult pancreas. Moreover, we identified Neurog3-independent ghrelin-expressing cells that have the potential to contribute to exocrine and ductal tissue.