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posted on 2013-01-25, 00:28 authored by Alessio Papi, Gianluca Storci, Tiziana Guarnieri, Sabrina De Carolis, Sara Bertoni, Nicola Avenia, Alessandro Sanguinetti, Angelo Sidoni, Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Marina Orlandi, Massimiliano Bonafé

TAF secreted TGFβ induces TNFα expression in breast CSCs. TNFα binds TNFR1 on breast CSCs and activates the PPARα/HIF1α interplay which up-regulates miR130b expression. The interplay is counterbalanced by PPARγ via miR17-5p up-regulation. In turn, the PPARα/HIF1α interplay regulates CAIX, ApoE, IL6 and SLUG expression.

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Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells
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immunologycell biologyoncologypathology

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