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Schematic model of a putative mechanism for prostate cancer cell proliferation via microRNA regulation of PTEN and its downstream signals.

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posted on 30.09.2013, 07:36 by Ling Tian, Yu-xiang Fang, Jing-lun Xue, Jin-zhong Chen

Increased amount of miR-19b, miR-23b, miR-26a and miR-92a may impose inhibitory effects on PTEN, PI3K/Akt signaling components, and cyclin D1, respectively. The expression level of PI3-kinase, Akt and cyclin D1 was associated with the expression level of relevant upstream regulators and the regulation of the relevant miRNAs.