pone.0128648.g009.tif (716.05 kB)
Download fileSchematic demonstrating HO-1 induction attenuates fructose-induced hepatic lipid deposition, prevent the development of hepatic fibrosis and abate NAFLD-associated vascular dysfunction; effects that are mediated by activation of the SIRT1 gene expression.
figure
posted on 2015-06-22, 02:44 authored by Komal Sodhi, Nitin Puri, Gaia Favero, Sarah Stevens, Charles Meadows, Nader G. Abraham, Rita Rezzani, Hayden Ansinelli, Edward Lebovics, Joseph I. ShapiroSchematic demonstrating HO-1 induction attenuates fructose-induced hepatic lipid deposition, prevent the development of hepatic fibrosis and abate NAFLD-associated vascular dysfunction; effects that are mediated by activation of the SIRT1 gene expression.
History
Usage metrics
Categories
Keywords
induced obesity createshepatocyte lipid accumulationdecreasing vascular dysfunctionassociated vascular dysfunctionoxidative environment conducivealcoholic fatty livermediated lipid accumulationhigh fructose dietdecreasing oxidative stressnafld ), obesitydetermine whether hotriglycerides levels suggestingfructose mediated nonhepatocytes increased fasoxidative stresstriglycerides levelsincreased levelsliver alongfructose ).ameliorated fructosesirt1 levelsxlink ">murine hepatocytesmetabolic syndromelipogenesis alongkey roleho activityheme oxygenasefirst timedependent dedecreased hocvd ).concurrent treatmentcardiovascular diseaseblood pressureattenuate steatohepatitisabates nafld05 vs05 ).