Schema of exocyst-dependent glucose uptake and FFA uptake.

The translocation/fusion of Glut4-containing vesicles and FFA uptake are both regulated by the exocyst complex downstream of PI3-kinase and Akt. The exocyst functions in concert with other modifiers such as small GTPases, TBK1, and SNARE proteins that together coordinate adipocyte glucose uptake and FFA uptake.