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Schema of exocyst-dependent glucose uptake and FFA uptake.

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posted on 2015-03-13, 04:29 authored by Mayumi Inoue, Takeshi Akama, Yibin Jiang, Tae-Hwa Chun

The translocation/fusion of Glut4-containing vesicles and FFA uptake are both regulated by the exocyst complex downstream of PI3-kinase and Akt. The exocyst functions in concert with other modifiers such as small GTPases, TBK1, and SNARE proteins that together coordinate adipocyte glucose uptake and FFA uptake.