Schema: GEC-derived SFRP5 inhibits Wnt5a-induced macrophage chemotaxis and activation.
figureposted on 08.01.2014, 03:00 by Chenghai Zhao, Xianmin Bu, Wei Wang, Tingxian Ma, Haiying Ma
Wnt5a chemoattracts macrophages by upregulate CCL2 expression, and activates macrophages to secrete cytokines, which are blocked by GEC-derived SFRP5.
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Anatomy and physiologyImmune physiologyImmune cellsimmunologyMolecular cell biologyCellular typesEpithelial cellsSignal transductionSignaling cascadesWnt signaling cascadeClinical immunologyGastroenterology and hepatologyGastrointestinal cancersGastrointestinal infectionsStomach and duodenumoncologygec-derivedsfrp5inhibitswnt5a-inducedmacrophagechemotaxis