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Safety analysis in healthy rats.

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posted on 21.12.2012 by Kishore Golla, Bhaskar Cherukuvada, Farhan Ahmed, Anand K. Kondapi

Lactodoxonano, Apodoxonano and Doxo (800 µg of drug equivalent) were administered intravenously (i.v.). Safety analysis was carried out using biochemical kits. Heart toxicity was measured in terms of Glutathione peroxidase and LDH. Both the enzymes showed minimal expression when treated with nanoformulations as that of the control but gets increased during Doxo treatment. Kidney toxicity was evaluated by the levels of Creatinine, Blood Urea Nitrogen, whereas the Liver toxicity was estimated in terms of SGOT and SGPT levels. The level of these 4 markers also followed the same pattern as that of Glutathione peroxidase and LDH i.e., they showed minimal levels as that of control when treated with nanoformulations opposite to Doxo.

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