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SPM results for the voxel-wise correlation between changes in metabolism and changes in self-reports of cocaine craving (Neutral - Cocaine-cues) for the Placebo and the Methylphenidate conditions (p<0.005 uncorrected, cluster size >200 voxels).

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posted on 09.07.2010, 00:23 by Nora D. Volkow, Gene-Jack Wang, Dardo Tomasi, Frank Telang, Joanna S. Fowler, Kith Pradhan, Millard Jayne, Jean Logan, Rita Z. Goldstein, Nelly Alia-Klein, Christopher Wong

For Placebo the correlations were negative (decreases in metabolism associated with increases in craving) whereas with Methylphenidate these were positive (increases in metabolism associated with increases in craving).