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Role of nitric oxide and the endothelium.

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posted on 14.03.2014, 03:14 by Fouad Amraoui, Léon Spijkers, Hajar Hassani Lahsinoui, Liffert Vogt, Joris van der Post, Stephan Peters, Gijs Afink, Carrie Ris-Stalpers, Bert-Jan van den Born

A) Effect of eNOS inhibition with L-NAME (N = 5) and endothelium (EC) denudation (N = 4) on ET-1 concentration-response curves in carotid segments of vehicle-treated mice (Cntrl). Data are expressed as mean±SEM, *(maximal efficacy of Cntrl vs. Cntrl + L-NAME and Cntrl vs. Cntrl + EC denuded, N = 9–5, p<0.05). B) Effect of L-NAME (N = 4) and EC denudation (N = 3) on ET-1 concentration-response curves in carotid segments of sFlt-1-treated mice. C) Metacholine concentration-response curve generated after pre-constriction with the α1-adrenergic receptor agonist phenylephrine. Data are expressed as mean±SEM,*(maximal relaxation sFlt-1 vs. Cntrl, N = 13–14, p<0.05).

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