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Response to doxorubicin at 72 h is revealed with [11C]-AnxA5-ST but not [18F]-FDG or [11C]-mTrx-GFP-ST.

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posted on 01.08.2012, 02:25 by Qing Cheng, Li Lu, Jonas Grafström, Maria Hägg Olofsson, Jan-Olov Thorell, Erik Samén, Katarina Johansson, Hanna-Stina Ahlzén, Sharon Stone-Elander, Stig Linder, Elias S. J. Arnér

Representative MIP and transaxial images of radioactivity (summed over 35–55 min) after tail vein injection in mice with FaDu xenografts of A) [11C]-AnxA5-ST or B) [11C]-mTrx-GFP-ST, 72 h after treatment with a single dose of doxorubicin (5 mg/kg). Also shown are representative images of [18F]-FDG, at C) baseline or, alternatively, D) after treatment with doxorubicin and 90 min after the image with [11C]-AnxA5-ST in A). E) Time activity curves of single tumors showing uptake of [11C]-AnxA5-ST (solid triangles and squares) or [18F]-FDG (lines) before (solid triangle and dashed line) or after doxorubicin treatment (solid squares and solid line). F) Corresponding experiments showing a comparison between of [11C]-mTrx-GFP-ST (empty triangles and squares) and [18F]-FDG (lines) tumor uptake in the same mouse before (empty triangles and dashed line) or after doxorubicin treatment (empty squares and solid line).

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