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Regulatory roles for Clims in normal development and cancer.

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posted on 31.07.2014, 03:12 by Michael L. Salmans, Zhengquan Yu, Kazuhide Watanabe, Eric Cam, Peng Sun, Padhraic Smyth, Xing Dai, Bogi Andersen

Clims promote branching morphogenesis and carcinogenesis in the mammary gland (left). Direct regulation of Fgfr2 expression by Clims and LMO4 in the basal cell compartment facilitate basal stem cell self-renewal (right). Clims mediate a transcriptional program within the basal cell compartment to promote expression of Fgfr2, ErbB2, and ErbB3 in the luminal cell compartment, in addition to maintaining luminal epithelial cell fate by restricting the expression of epidermal differentiation genes.