Reduced functional connectivity of the thalamus in schizophrenia.

(A) Statistical significance (t-scores) of decreases in the positive (blue-cyan) and negative (red-yellow) FC of the thalamus in schizophrenia (N  =  69) compared to healthy controls (N  =  74), superimposed on lateral and medial surface views of the cerebrum and anterior and posterior surface views of the cerebellum. (B) Average ROI measures of thalamic FC across subjects for selected ROIs (0.9 mm cubes; 27 voxels) centered at the MNI coordinates listed in Table S3, showing the lower absolute FC for schizophrenia patients than for controls in thalamus (THA), orbitofrontal cortex (OFC; BA 11), posterior lobe of the cerebellum (CBL), posterior cingulum (PCC) (positive connectivity: blue arrows; P < 0.0005), and for superior and middle temporal (STG and MTG; BA 22) and postcentral (PCG; BA 3) gyri and cuneus (BA 19) (negative connectivity: orange arrows; P < 0.0005). MNI coordinates of the bilateral cubic seed (54 voxels) in the thalamus: x  =  ±6 mm; y  =  −3 mm; and z  =  0 mm.