Figure_5.tif (1.47 MB)
Download file

Recognition memory and learning in PLB1 mice.

Download (0 kB)
posted on 11.11.2011, 01:12 by Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riedel

A: Social recognition. Time (in seconds) spent with an unfamiliar stranger mouse (S1) and the corresponding empty compartment (E) at 5 and 12±1 months of age. During sociability (left), all groups spent significantly more time in the vicinity of the unfamiliar mouse compared to the empty holder. During the social memory phase (right), PLB1WT mice discriminated between the now more familiar first stranger (S1*) and a novel, unfamiliar stranger (S2) in both age groups. PLB1Triple only discriminated between the conspecifics at 5 months. Data are represented as means+SEM; n.s.: not significant; *: P<0.05; **:P<0.01; ***: P<0.001, arena and representative exploration patterns are also depicted. B: Object recognition and spatial novelty. Time (in %+SEM) spent with a novel object (left) or relocated object (right) in PLB1WT and PLB1Triple mice at 8 and 12±1 months. PLB1Triple performed worse than PLB1WT in both age groups during object recognition and did not discriminate between novel and familiar object at 12 months of age. At this age, recognition of spatial novelty was also affected. Significances are indicated between groups (*), a comparison with chance level is also given ($:P<0.05; $$: P<0.01; $$$: P<0.001). Examples path trajectories are illustrated on the right. C: Water maze learning. Mean daily path length (+ or − SEM) to reach a visible (V) platform, followed by spatial training to a submerged platform (days 1–4). At 5 and 12 months, PLB1Triple mice were able to locate the visible platform, but were significantly impaired at 12 (but not 5) months in the hidden platform task compared to PLB1WT (P<0.05). Arena set up with representative exploration patterns for day 1–4 (swim path) are depicted.


Usage metrics