Radio-frequency electromagnetic field (RF EMF) stimulation elicits post-neurotomy pain.
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(A) Hollow circles indicate the summed response score for each animal for both TNT (red) and SHAM (grey) groups. Only one behavioral pain response was observed in the SHAM group over all 10 experimental trials. Statistically significant mean response scores (solid black line) were observed between TNT and SHAM groups beginning in week 2 and continuing through week 8. Lidocaine was found to be a successful moderator of RF EMF-induced neuroma pain. Dashed black lines indicate population median. (B) Following bulb resection surgery, significant RF EMF-induced neuroma pain persisted from week 5 until week 28. For statistical comparisons, a two-tailed Mann-Whitney test was used (* p<0.05, ** p<0.01). (C) RF EMF exposure induces mean skin temperature increase. A mean skin temperature increase of 2.2°C was observed following 10 minutes of RF EMF exposure. (D) Recovery/Stimulus behavioral response ratios for all time points.