RNA editing efficiency is highly regulated between different areas of the nervous system.

<p>(A) An example of the fluorescent poison-primer extension assay <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000540#pbio.1000540-Roberson1" target="_blank">[26]</a> used to measure the frequency of the I877V edit in the giant fiber lobe (GFL; giant axon system) and the optic lobe (OL) neurons. (B) Cumulative results from a broad range of tissues (all numbers are expressed as mean ± s.d. <i>N</i> = 4 for each tissue). To determine the editing efficiency of all four editing sites in different tissues, the full-length SqNaKα1 cDNA was amplified using cDNA specific to different regions of the <i>Loligo</i> nervous system <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000540#pbio.1000540-Young1" target="_blank">[42]</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000540#pbio.1000540-Young2" target="_blank">[43]</a> and then used as a template for the assay.</p>