R1629Q mutation affects the time course of current decay.
(A) Example current traces of WT (open circle) and R1629Q (filled square) channels.
(B) A shows typical normalized current traces recorded in response to - 40mV step for WT (solid line) and R1629Q (dash line) SCNA5 channels. The decay of INa was fit to a mono-exponential (τ time constants) decay function. Note that the decay of the R1629Q channels was faster than WT. (C) Current decay time constants for WT (open circle) and R1629Q (filled square) between -50mV and 30mV.*P<0.05 vs. WT in this study. Results are expressed as means±SE for 6 to 11 cells.