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R1629Q enhances Nav1.5 channel into intermediate inactivation.

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posted on 22.10.2013, 03:15 by Zhipeng Zeng, Jieqiong Zhou, Yuxi Hou, Xiaojing Liang, Ziguan Zhang, Xuejing Xu, Qiang Xie, Weihua Li, Zhengrong Huang

(A) Time dependence of intermediate inactivation for WT and R1629Q.The two-pulse protocol is shown in the Inset. Differences between WT (open circle, n=9) and R1629Q (filled squre, n=8) were significant at all prepulse durations from 1 to 1000ms. (B)Activity-dependent loss of sodium channel availability. Sodium currents are recorded during series trains of 300ms depolarization to -20mV from holding potential -120mV.Currents are normalized to the value obtained after the first pulse and plotted against the successive pulse number. The residual normalized current level recorded after 30th pulse is 39.4%±2.1% for WT (open circles, n=14) and 18.7%±2.1% for R1629Q (filled squares, n=15) (P<0.01).

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