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Quantification of gelatinase activities in cortical extracts 6 hours after insults in P5 mice.

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posted on 06.08.2013, 01:32 authored by Priscilla L. Omouendze, Vincent J. Henry, Baptiste Porte, Nicolas Dupré, Peter Carmeliet, Bruno J. Gonzalez, Stéphane Marret, Philippe Leroux

MMP-2 (A,C,E) and MMP-9 (B,D,F) gelatinolytic activities measured in hypoxia-ischemia (A,B), ibotenate excitotoxic paradigm (C,D) and PBS injection trauma (E,F). Data are expressed relative to the average densitometry in WT mice. * indicate significant difference with activity in respective controls, i.e. WT sham operated (A,B), PBS injected (C,D) or non-treated animals (E,F). *p<0.05; **p<0.01; ***p<0.001 vs WT controls, ##p<0.001 and ###p<0.001 vs PAI-1−/− controls. Numbers in parentheses indicate the number of animals used. ND; non detected upon standard incubation.